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Actually, drugs are responsible for a large number of cases of acute liver failure.1 Acetaminophen accounts for the approximately half of cases of DILI in the United States.2 In other world's regions, for instance in developing countries, other drugs such as antituberculosis medications might be the leading cause of DILI.3 In some cases of DILI such as acetaminophen-induced hepatotoxicity, the mechanism of liver injury is fairly well understood, hepatic damage is dose dependent, and the toxicity is reproducible in animal models

The weight loss data is similar across both, though results vary